Moreover, recent investigations have been focused on extracellular matrices (ECMs) (370 publications), hydrogel materials (286 publications), and drug delivery systems (220 publications). The most prolific journal in the BRM field was Acta Biomaterialia, closely followed by Biomaterials. The most productive countries were China, United States, and Italy. The study applied bibliometric methods and knowledge visualization techniques to identify and investigate publications based on the publication year (between 20), document type, language, country, institution, author, journal, keywords, and citation number. A comprehensive literature review using formal data mining procedures was performed to explore the global trends of selected areas of research for the past 20 years. The aim of this study was to comprehensively assess the existing research and recent progress on BRMs, thus providing useful insights into contemporary research, as well as to explore potential future directions within the scope of bone regeneration therapy. With advances in BRMs technologies, new strategies are emerging to promote bone regeneration. Bone regeneration materials (BRMs) bring us new sights into the clinical management bone defects.
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